Endocrine Abstracts

The hypothalamic-pituitary-adrenal (HPA) axis is the main stress-responsive neuroendocrine system in humans. Glucocorticoids (GC) constitute the principal systemic mediators of HPA axis function by governingmetabolic and behavioural responses to stress. Those include the modulation of transcriptional processes through the coordinated action of glucocorticoid (GR) and mineralocorticoid (MR) receptors. To study the effects of systemic malfunctioning of the HPA axis on the develo...